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288144

Sigma-Aldrich

Tricarbonyldichlororuthenium(II) dimer

Synonyme(s) :

CORM-2

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About This Item

Formule linéaire :
[Ru(CO)3Cl2]2
Numéro CAS:
22594-69-0
Poids moléculaire :
512.01
Numéro MDL:
MFCD00011528
Code UNSPSC :
12161600
ID de substance PubChem :
24857320
Nomenclature NACRES :
NA.22

Niveau de qualité

100

Pertinence de la réaction

core: ruthenium
reagent type: catalyst

Chaîne SMILES 

[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl

InChI

1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4

Clé InChI

JYHHJVKGDCZCCL-UHFFFAOYSA-J

Application

Carbon monoxide-releasing molecule used for pharamological studies including:
  • Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
  • Investigations of P2X4 as a possible target
  • Possible modification of thrombus growth or disintegration
  • Enhances fibrinogen as a substrate for thrombin
  • Regulation of ion transport by gasotransmitters

Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCR0080
MKCN3020
MKCG1927
MKCD8365
MKCB0224V

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Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12)
Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO.
Yu Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 36(6), 791-795 (2016-12-08)
Carbon monoxide (CO), as a vital small molecule in signaling pathways, is found to be involved in ischemia-reperfusion injury (IRI) in renal transplantation. CO-releasing molecule-2 (CORM-2), a CO-releasing molecule, is a type of metal carbonyl complexes which can quickly release
Francisco J Ibáñez et al.
Frontiers in microbiology, 8, 2108-2108 (2017-11-23)
Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can be positively modulated by
V G Nielsen et al.
Human & experimental toxicology, 36(7), 727-733 (2016-08-05)
Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of
Vance G Nielsen
International journal of molecular sciences, 21(8) (2020-04-29)
The demonstration that carbon monoxide releasing molecules (CORMs) affect experimental systems by the release of carbon monoxide, and not via the interaction of the inactivated CORM, has been an accepted paradigm for decades. However, it has recently been documented that
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