177989

Isobutyl chloroformate

98%

• Synonyme(s) : Chloroformic acid isobutyl ester, IBCF
• Formule linéaire : ClCO₂CH₂CH(CH₃)₂
• Numéro CAS: 543-27-1
• Poids moléculaire : 136.58
• Numéro Beilstein : 956590
• Numéro CE : 208-840-1
• Numéro MDL: MFCD00000642
• Code UNSPSC : 12352100
• ID de substance PubChem : 24850706
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: 0.33 mmHg ( 20 °C)
• Pureté: 98%
• Forme: liquid
• Indice de réfraction: n20/D 1.407 (lit.)
• Point d'ébullition: 128.8 °C (lit.)
• Solubilité: benzene: miscible; chloroform: miscible; diethyl ether: miscible
• Densité: 1.053 g/mL at 25 °C (lit.)
• Groupe fonctionnel: chloro
• Chaîne SMILES: CC(C)COC(Cl)=O
• InChI: 1S/C5H9ClO2/c1-4(2)3-8-5(6)7/h4H,3H2,1-2H3
• Clé InChI: YOETUEMZNOLGDB-UHFFFAOYSA-N

Description

Description générale

Isobutyl chloroformate is used as a peptide reagent. In oligonucleotide synthesis, IBCF blocks the 5′-hydroxyl function of deoxyribosides. It also serves as condensing reagent.

Application

• Preparation of a volatile derivative of taurine and application to gas chromatographic determination of urinary taurine.: Demonstrates the utility of isobutyl chloroformate in preparing volatile derivatives of taurine for gas chromatographic analysis, offering a methodological advancement in clinical biochemistry (Masuoka et al., 1989).
• Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition.: This article investigates the synthesis and biological activity of quinazoline antifolates, using techniques including isobutyl chloroformate, relevant in medicinal chemistry and drug development (Pawelczak et al., 1989).
• Coupling of peptides to protein carriers by mixed anhydride procedure.: Discusses a novel technique using isobutyl chloroformate for peptide coupling to proteins, useful in bioconjugate chemistry and vaccine development (Samokhin & Filimonov, 1985).
• Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.: Investigates the role of isobutyl chloroformate in synthesizing folate analogues for cancer research, showing its importance in therapeutic chemistry (Nair et al., 1981).

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H226,H302,H314,H330
• Conseils de prudence: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 96.8 °F - closed cup
• Point d'éclair (°C): 36 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter