157201
Sodium aurothiomalate hydrate
Synonyme(s) :
(1,2-Dicarboxyethylthio)gold disodium salt hydrate, Gold sodium thiomalate hydrate, Mercaptobutanedioic acid gold(I) disodium salt
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About This Item
Formule linéaire :
NaO2CCH2CH(SAu)CO2Na · xH2O
Poids moléculaire :
390.08 (anhydrous basis)
Numéro MDL:
Code UNSPSC :
12352100
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Produits recommandés
Forme
powder
Niveau de qualité
Chaîne SMILES
O.[Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O
InChI
1S/C4H6O4S.Au.2Na.H2O/c5-3(6)1-2(9)4(7)8;;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;;1H2/q;3*+1;/p-3
Clé InChI
YLQOAPBVYJCTPW-UHFFFAOYSA-K
Description générale
Sodium aurothiomalate has antirheumatic properties and exhibits inhibitory effects against M. tuberculosis.
Application
Sodium aurothiomalate hydrate was used in the high mobility group box chromosomal protein 1 (HMGB1) western blotting.
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Les clients ont également consulté
Kathryn E A Lougheed et al.
Tuberculosis (Edinburgh, Scotland), 89(5), 364-370 (2009-08-25)
Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs
Cecilia K Zetterström et al.
Journal of leukocyte biology, 83(1), 31-38 (2007-10-05)
Gold compounds such as gold sodium thiomalate (GST) can reduce the symptoms of rheumatoid arthritis (RA), although their mechanism of action is not well defined. As the proinflammatory mediator high mobility group box chromosomal protein 1 (HMGB1) may play a
Christoph Tabeling et al.
Journal of vascular research, 52(4), 279-288 (2016-02-20)
Pulmonary vascular hyperresponsiveness is a main characteristic of pulmonary arterial hypertension (PAH). In PAH patients, elevated levels of the vasoconstrictors thromboxane A2 (TXA2), endothelin (ET)-1 and serotonin further contribute to pulmonary hypertension. Protein kinase C (PKC) isozyme alpha (PKCα) is
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Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of
Farivash Darabi et al.
Journal of inorganic biochemistry, 149, 102-107 (2015-04-14)
Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold
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