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33998

Supelco

Melengestrol acetate

VETRANAL®, analytical standard

Synonym(s):

17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione, MGA

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About This Item

Empirical Formula (Hill Notation):
C25H32O4
CAS Number:
Molecular Weight:
396.52
Beilstein:
2066919
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

202-204 °C (lit.)

application(s)

clinical testing

format

neat

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

InChI

1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

InChI key

UDKABVSQKJNZBH-DWNQPYOZSA-N

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General description

Melengestrol acetate belongs to the family of hormones. This acetylgestagen compound is known to elicit a gestagenic effect in vivo.

Application

Melengestrol acetate may be used as a reference standard for the determination of the analyte in:
  • Milk using turborFlow online solid phase extraction (SPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Kidney fats by ultra-performance convergence chromatography-tandem mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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Simultaneous determination of seven gestagens in kidney fats by Ultra Performance Convergence Chromatography tandem mass spectrometry.
Tao Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 988, 143-148 (2015)
Rapid determination of 88 veterinary drug residues in milk using automated TurborFlow online clean-up mode coupled to liquid chromatography-tandem mass spectrometry.
Zhu WX, et al.
Talanta, 148, 401- 411 (2016)
K Y Chung et al.
Journal of animal science, 87(12), 3897-3904 (2009-08-18)
Melengestrol acetate (MGA) has been used in the United States for nearly 40 yr to enhance feedlot heifer performance, yet unequivocal studies have not been conducted to discover the mechanism of action. Our hypothesis was that MGA may induce various
M E Corrigan et al.
Journal of animal science, 85(7), 1770-1779 (2007-03-21)
Previous research from our laboratory has indicated that melengestrol acetate (MGA) added to the diet during the first 35 d after arrival in the feedlot improves growth rates and tends to reduce chronic respiratory disease in heifers naturally challenged with
A Moresco et al.
Veterinary pathology, 46(6), 1117-1128 (2009-07-17)
As husbandry practices have improved, safe and effective contraception for captive wildlife management has become a necessity. Melengestrol acetate (MGA), a synthetic progestin, is highly effective and has been used in many zoo species. Long-term use of MGA has been

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