SAB4503508

Anti-WAVE1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): KIAA0269, SCAR1, Verprolin homology domain-containing protein 1, WAS1, WASF1
• MDL number: MFCD04118689
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 61 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q92558
• UniProt accession no.: Q92558
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... WASF1(8936)

Description

General description

Wiskott–aldrich syndrome protein family member 1 (WAVE1) is encoded by the gene mapped to human chromosome 6q21-22. It is primarily expressed in brain and is characterized with a tripartite VCA (verprolin homology, cofilin homology and acidic) domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human WAVE1.

Immunogen Range: 91-140

Application

Anti-WAVE1 antibody produced in rabbit has been used in immunoblotting.[1]

Biochem/physiol Actions

Members of WASP-family verprolin-homologous protein (WAVE) family plays a vital role in actin polymerisation and cytoskeletal organisation, which are essential for various cellular processes, including cell shape changes, cytokinesis, cell motility and membrane traffic. WAVE1 regulates chemoresistance during autophagy. The encoded protein plays an essential role in oligodendrocyte morphogenesis and myelination. In addition, it is also implicated in regulation of spine morphogenesis. Overexpression of the gene leads to the development of prostate cancer.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable