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PHL89811

Triptolide

phyproof® Reference Substance

Synonyme(s) :

PG 490

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About This Item

Formule empirique (notation de Hill):
C20H24O6
Numéro CAS:
38748-32-2
Poids moléculaire :
360.40
Numéro MDL:
MFCD00210565
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

primary reference standard

Gamme de produits

phyproof® Reference Substance

Pureté

≥98.0% (HPLC)

Fabricant/nom de marque

PhytoLab

Application(s)

food and beverages

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

Clé InChI

DFBIRQPKNDILPW-KTGKZQHOSA-N

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Catégories apparentées

Description générale

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Actions biochimiques/physiologiques

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.

Informations légales

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H300 + H330,H361f

Classification des risques

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
77930914

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Consulter la Bibliothèque de documents

Tsung-Han S Hsieh et al.
Molecular cell, 78(3), 539-553 (2020-03-28)
Whereas folding of genomes at the large scale of epigenomic compartments and topologically associating domains (TADs) is now relatively well understood, how chromatin is folded at finer scales remains largely unexplored in mammals. Here, we overcome some limitations of conventional
Yicheng Long et al.
Nature genetics, 52(9), 931-938 (2020-07-08)
Many chromatin-binding proteins and protein complexes that regulate transcription also bind RNA. One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27me3 mark of facultative heterochromatin and is required for stem cell differentiation. PRC2 binds RNAs broadly in vivo

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