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59356-U

Supelco

Discovery® Cyano (5 µm) HPLC Columns

Discovery® Cyano HPLC Column

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonyme(s) :

Cyano Bonded Phase Column

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About This Item

Code UNSPSC :
41115700
eCl@ss :
32110501
Nomenclature NACRES :
SB.52
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Nom du produit

Colonne de HPLC Discovery® Cyano, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Matériaux

stainless steel column

Niveau de qualité

100

Agence

suitable for USP L10

Gamme de produits

Discovery®

Caractéristiques

endcapped

Fabricant/nom de marque

Discovery®

Conditionnement

1 ea of

Ampleur du marquage

4.5% Carbon loading

Paramètres

≤70 °C temp. range
400 bar pressure (5801 psi)

Technique(s)

HPLC: suitable
LC/MS: suitable

L × D.I.

15 cm × 4.6 mm

Superficie

200 m2/g

Couverture de surface

3.5 μmol/m2

Impuretés

<10 ppm metals

Matrice

silica gel, high purity, spherical base material
fully porous particle

Groupe de la matrice active

cyano phase

Taille des particules

5 μm

Dimension de pores

180 Å

Plage de pH de fonctionnement

2-8

Application(s)

food and beverages

Technique de séparation

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Catégories apparentées

Description générale

Discovery® Cyano HPLC column is used for the retention and separation of strongly basic analytes including quaternary ammonium salts, with excellent peak shapes.

Caractéristiques et avantages

  • Faible hydrophobicité pour l'élution rapide des analytes hydrophobes
  • Forme excellente des pics avec rétention des analytes fortement basiques
  • Rétention des analytes polaires
  • Sélectivité unique
  • Rétention sensiblement réduite par rapport à C18 (nécessite généralement une phase mobile organique à plus faible %)
  • Séparations LC-MS stables à faible diffusion
  • Compatible avec les phases organiques très aqueuses

Informations légales

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
295280-06
295280-05
295280-04
295280-03
295280-02

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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

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Supelco

59354-U

Colonne HPLC Discovery® C8

Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
T A Verdoorn et al.
European journal of pharmacology, 269(1), 43-49 (1994-09-15)
The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish between different structural isoforms have not
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Questions

1–4 sur 4 questions  

  1. ¿Me podrías confirmar que la composición de esta columna es end-capped cyanosilyl silica gel for chromatography R? Gracias!

    1 réponse

    1. These columns are end-capped, but the phase is cyanopropyl.

      Utile ?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile ?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile ?

  4. Please provide the below details for the column Carbon loading%- Pore size- Surface area- pH stability- End capping-

    1 réponse

    1. TS Answer:
      - 4.5% Carbon loading
      - Pore size: 180 Å
      - Surface area: 200 m2/g
      - Operating pH range: 2-8
      - Endcapped
      - Particle Size: 5 μm
      - Temperature Range: ≤70 °C
      - Maximum Pressure: 400 bar pressure (5801 psi)
      - Suitable for USP L10

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Évaluations

Filtres actifs

  1. India
    • Avis 1
    • Votes 0
    2 sur 5 étoiles.

    Column to column variation

    Variation in Retention time from column to column observed

    Traduire avec Google

    Utile ?

    1. Réponse de Sigma-Aldrich Corporation :

      Thank you for your review. While minor variability between batches may occur, the degree of difference in retention times would be impacted by run times. Assuming all other conditions are identical, an overall +/- 5% may be possible. As there are a number of variables to consider, we encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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