Z4250

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

• Synonyme(s) : Yeast Cell Wall
• Numéro CAS: 58856-93-2
• Numéro MDL: MFCD00082157
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: Saccharomyces cerevisiae
• Forme: powder with small lumps
• Technique(s): flow cytometry: suitable; tissue culture: suitable
• Couleur: off-white to light brown
• Température de stockage: 2-8°C

Description

Application

• in flow cytometry
• to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)

Zymosan A from Saccharomyces cerevisiae has been used:

• as a positive control to determine the activation of complement cascade
• for respiratory burst (RB) assay
• to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
• a stimulating agent in Krebs-Ringer phosphate (KRP) medium
• to induce thermal hyperalgesia in mice

Actions biochimiques/physiologiques

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)