U3885

UK-78282 monohydrochloride

≥98% (HPLC)

• Synonyme(s) : 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride
• Formule empirique (notation de Hill) : C₂₉H₃₅NO₂HCl
• Numéro CAS: 136647-02-4
• Poids moléculaire : 466.05
• Numéro MDL: MFCD16875438
• Code UNSPSC : 12352200
• ID de substance PubChem : 329827628
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1
• InChI: 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
• Clé InChI: ZZSQARULZYQMIG-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels.

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H319,H400
• Conseils de prudence: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Classification des risques: Aquatic Acute 1 - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable