SML2951

SGC-CK2-1

≥98% (HPLC)

• Synonyme(s) : N-(5-(3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-methylphenyl)propionamide
• Formule empirique (notation de Hill) : C₂₀H₂₁N₇O
• Numéro CAS: 2470424-39-4
• Poids moléculaire : 375.43
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: [n]21ncc(c2nc(cc1NC4CC4)Nc3cc(c(cc3)C)NC(=O)CC)C#N
• Clé InChI: YKDZIFFKQUNVHH-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Potent and highly selective casein 2 (CK2, CKII) inhibitor with potent cellular activity, but no antiproliferation efficacy in HCT116 or U-87 MG cancer cultures.

SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α′ IC₅₀ = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC₅₀ = 440 nM, IC₅₀≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α′ IC₅₀ = 36/16 nM by cellular NanoBRET assay).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable