SML0844

GNF 5837

≥98% (HPLC)

• Synonyme(s) : N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
• Formule empirique (notation de Hill): C₂₈H₂₁F₄N₅O₂
• Numéro CAS: 1033769-28-6
• Poids moléculaire : 535.49
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: yellow to orange
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: FC(F)(F)c1cc(c(cc1)F)NC(=O)Nc2cc(c(cc2)C)Nc3cc4c(cc3)\C(=C\c5[nH]ccc5)\C(=O)N4
• InChI: 1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
• Clé InChI: YYDUWLSETXNJJT-MTJSOVHGSA-N

Description

Actions biochimiques/physiologiques

GNF-5837 is a selective Trk inhibitor.

GNF-5837 is an orally bioavailable Trk inhibitor (IC₅₀ = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC₅₀ values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable