P215

PD 98,059

solid

• Synonyme(s) : 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
• Formule empirique (notation de Hill): C₁₆H₁₃NO₃
• Numéro CAS: 167869-21-8
• Poids moléculaire : 267.28
• Numéro MDL: MFCD00671789
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278666
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Couleur: yellow
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
• InChI: 1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
• Clé InChI: QFWCYNPOPKQOKV-UHFFFAOYSA-N
• Informations sur le gène: human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

Description

Application

PD 98,059 has been used:

• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
• in culture medium for cell migration assay

Actions biochimiques/physiologiques

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Caractéristiques et avantages

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold with permission of Warner Lambert Company.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves