SBR00001

Vancomycin hydrochloride

Ready Made Solution, 100 mg/mL in DMSO

• Synonyme(s) : Vancomycin HCL
• Formule empirique (notation de Hill) : C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
• Numéro CAS: 1404-93-9
• Poids moléculaire : 1449.25 (free base basis)
• Code UNSPSC : 51282703
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: Streptomyces orientalis
• Niveau de qualité: 200
• Forme: liquid
• Concentration: 100 mg/mL in DMSO
• Couleur: colorless to faint tan
• Spectre d'activité de l'antibiotique: Gram-positive bacteria
• Mode d’action: cell wall synthesis | interferes
• Température de stockage: −20°C
• Chaîne SMILES: [Cl-].Clc1c2ccc(c1)[C@H]([C@@H]3NC(=O)[C@H](NC(=O)[C@@H]6NC(=O)[C@@H](NC(=O)[C@@H]([C@@H](c7cc(c(cc7)Oc8c(c(cc6c8)O2)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O[C@@H]%10O[C@H]([C@H]([C@](C%10)(N)C)O)C)O)O)CO)Cl)O)NC(=O)[C@H]([N+H2]C)CC(C)C)CC(=O)N)c4cc(c(cc4)O)c
• InChI: 1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
• Clé InChI: LCTORFDMHNKUSG-XTTLPDOESA-N

Description

Description générale

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys.[1] It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.[2]

Application

Vancomycin hydrochloride may be used-

• for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions[3]
• for the estimation of biomass in a culture of various strains of bacteria[4]
• as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.[5]

Actions biochimiques/physiologiques

Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme.[2]

Conditionnement

10ML

Stockage et stabilité

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334
• Conseils de prudence: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Classification des risques: Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - closed cup
• Point d'éclair (°C): 87 °C - closed cup