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O001

Sigma-Aldrich

β-Chlornaltrexamine dihydrochloride

solid

Synonyme(s) :

β-CNA

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About This Item

Formule empirique (notation de Hill):
C24H32Cl2N2O3 · 2HCl
Numéro CAS:
67025-98-3
Poids moléculaire :
540.35
Code UNSPSC :
12352116
ID de substance PubChem :
24897920
Nomenclature NACRES :
NA.77

Forme

solid

Contrôle du médicament

regulated under CDSA - not available from Sigma-Aldrich Canada

Couleur

white

Solubilité

H2O: soluble (use aqueous solutions immediately.)
ethanol: soluble (is stable for ca. 1 month in the freezer.)
polar organic solvents: soluble

Température de stockage

−20°C

Chaîne SMILES 

Cl.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(CCCl)CCCl)CC6CC6

InChI

1S/C24H32Cl2N2O3.2ClH/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15;;/h3-4,15,17,19,22,29-30H,1-2,5-14H2;2*1H/t17-,19-,22+,23+,24-;;/m1../s1

Clé InChI

JJZDLJGFHABVOM-QNWHWJQFSA-N

Actions biochimiques/physiologiques

Irreversible μ, δ and κ opioid receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Hygroscopic, photosensitive.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

R M Quock et al.
Brain research, 549(1), 162-164 (1991-05-17)
Nitrous oxide antinociception in the abdominal constriction test was significantly reduced in mice pretreated intracerebroventricularly (i.c.v.) with beta-chlornaltrexamine (beta-CNA). However, this antagonism was reversed when the beta-CNA was co-administered i.c.v. with the kappa-opioid ligand U-50,488H but not the mu-opioid ligand
Michael S Virk et al.
Molecular pharmacology, 73(4), 1301-1308 (2008-01-17)
Agonist-selective actions of opioids on the desensitization of mu-opioid receptors (MORs) have been well characterized, but few if any studies have examined agonist-dependent recovery from desensitization. The outward potassium current induced by several opioids was studied using whole-cell voltage-clamp recordings
T A Macey et al.
Neuroscience, 168(2), 543-550 (2010-04-17)
Microinjection of opioids into the ventrolateral periaqueductal gray (vlPAG) produces antinociception in part by binding to mu-opioid receptors (MOPrs). Although both high and low efficacy agonists produce antinociception, low efficacy agonists such as morphine produce limited MOPr internalization suggesting that
R B Raffa et al.
European journal of pharmacology, 244(3), 231-238 (1993-02-15)
Dissociation constants (KA) for [D-Pen2,5]enkephalin (DPDPE) inhibition of the electrically evoked twitch of the mouse isolated vas deferens preparation (MVD) were calculated at five temperatures (25, 30, 34, 37 and 40 degrees C). These values were determined from the equiactive
J R Nicholson et al.
Canadian journal of physiology and pharmacology, 76(3), 304-313 (1998-07-23)
We have exploited the availability of the "orphan" opioid receptor (referred to here as ORL1) in its "natural state" to investigate the effect of nociceptin (orphanin FQ), the endogenous agonist for the ORL1 receptor in the brain, vas deferens, and
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