M4154
β-N-Methylamino-L-alanine hydrochloride
Synonyme(s) :
L-BMAA
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About This Item
Formule empirique (notation de Hill):
C4H10N2O2 · HCl
Numéro CAS:
Poids moléculaire :
154.60
Numéro MDL:
Code UNSPSC :
12352200
Produits recommandés
Température de stockage
2-8°C
Chaîne SMILES
CNCC(N)C(O)=O
Actions biochimiques/physiologiques
Neuroexcitotoxic amino acid; may be involved in Guam amyotrophic lateral sclerosis
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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András Guseo
Orvosi hetilap, 153(52), 2060-2069 (2012-12-25)
Parkinson's disease is one of the most frequent progressive degenerative disorders with unknown origin of the nervous system. The commutation of the disease on Guam led to the discovery of a neurotoxin which was also found in other continents. This
Elijah W Stommel et al.
Medical hypotheses, 80(2), 142-145 (2012-12-19)
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island
Travis Rush et al.
Neuroreport, 23(4), 216-219 (2012-02-09)
Determination of the environmental factors involved in neurodegenerative diseases has been elusive. Methylmercury and β-N-methylamino-L-alanine (BMAA) have both been implicated in this role. Exposure of primary cortical cultures to these compounds independently induced concentration-dependent neurotoxicity. Importantly, concentrations of BMAA (10-100
Steven A Cohen
The Analyst, 137(9), 1991-2005 (2012-03-17)
The non-protein amino acid L-α-amino-β-methylaminopropionic acid (BMAA) has been linked to several neurodegenerative diseases. Its presence in trace amounts in complex sample such as bacterial, plant and mammalian tissue extracts and hydrolyzates makes analysis a complicated process requiring good analytical
Oskar Karlsson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 130(2), 391-404 (2012-08-09)
The cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) has been proposed to contribute to neurodegenerative disease. We have previously reported a selective uptake of BMAA in the mouse neonatal hippocampus and that exposure during the neonatal period causes learning and memory impairments in
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