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L6135

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

biotin conjugate, lyophilized powder

Synonyme(s) :

PNA, Peanut agglutinin

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1 MG
124,00 €
5 MG
473,00 €

124,00 €


Date d'expédition estimée le10 avril 2025


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1 MG
124,00 €
5 MG
473,00 €

About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

124,00 €


Date d'expédition estimée le10 avril 2025


Devis pour commande en gros

Conjugué

biotin conjugate

Niveau de qualité

Forme

lyophilized powder

Poids mol.

120 kDa

Composition

Protein, ≥80% Lowry

Ampleur du marquage

~3 mol biotin per mol protein

Technique(s)

blood typing: suitable
fractionation: suitable

Solubilité

water: 1.00-1.10 mg/mL, clear to slightly hazy, colorless

Température de stockage

2-8°C

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Description générale

Peanut lectin (PNA) is a lectin or an agglutinin from the legume, Arachis hypogaea,[1] found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3) N-acetylgalactosamine.[1]

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • in enzyme-linked micro plate assay to detect β-D-galactose-N-acetylglucosamine[2]
  • in Immunohistochemical double staining[3]
  • Immunohistochemical double staining for the detection of germinal centers[4]
  • in enzyme-linked microplate assayto detect β-D-galactose-N-acetylglucosamine[2]

Actions biochimiques/physiologiques

Lectin from Arachis hypogaea (peanut) functions as an antigenic determinant for Thomsen-Friedenreich antigen (TF)[5] and as mitogen for colorectal cancer stimulation cell division in normal colonic epithelium.[6] It is therefore used as tumor marker.[7]
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Conditionnement

Package size based on protein content.

Forme physique

Contains sodium citrate

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

In situ observation of germinal center cell apoptosis during a secondary immune response
Saitoh HA, et al.
Journal of Clinical and Experimental Hematopathology : JCEH, 46, 73-82 (2006)
Inhibition of influenza viral neuraminidase activity by collectins
Tecle T, et al.
Archives of Virology, 1731-1742 (2007)
Synthesis of glycopolymers and their multivalent recognitions with lectins
Ting SRS, et al.
Polym. Chem., 1, 1392-1412 (2010)
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus--infected mice
GeurtsvanKessel CH, et al.
The Journal of Experimental Medicine, 206, 2339-2349 (2009)
Andreia Valença et al.
Experimental eye research, 202, 108292-108292 (2020-10-17)
Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has

Questions

1–3 sur 3 questions  
  1. What is the Department of Transportation shipping information for this product?

    1 réponse
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. How does the storage temperature relate to shipping conditions?

    1 réponse
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  3. Is the peanut lectin (Lectin from Arachis hypogaea) a glycoprotein?  If so, what is the carbohydrate content?

    1 réponse
    1. Peanut lectin is not a glycoprotein. Although peanut lectin binds specifically to a particular carbohydrate (beta-gal(1-->3)galNac) in other molecules, the lectin itself does not contain any carbohydrate.  Please see page 231 of the following paper: R. Banerjee, et al., "Crystal structure of peanut lectin, a protein with an unusual quaternary structure".  Proc. Nat. Acad. Sci., USA, 91, 227-231 (1994).

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