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L0664

Sigma-Aldrich

Loxoprofen

solid

Synonyme(s) :

α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo

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About This Item

Formule empirique (notation de Hill):
C15H18O3
Numéro CAS:
68767-14-6
Poids moléculaire :
246.30
Numéro MDL:
MFCD00864331
Code UNSPSC :
12352200
ID de substance PubChem :
24278509
Nomenclature NACRES :
NA.77

Forme

solid

Auteur

Daiichi-Sankyo

Chaîne SMILES 

CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1

InChI

1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)

Clé InChI

YMBXTVYHTMGZDW-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS1(5742) , PTGS2(5743)

Application

Anti-inflammatory; analgesic

Caractéristiques et avantages

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Misato Hashizume et al.
Modern rheumatology, 20(5), 432-438 (2010-04-22)
We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study
Yasushi Kuribayashi et al.
The journal of obstetrics and gynaecology research, 43(9), 1465-1471 (2017-07-15)
We aimed to determine the frequency of endometrial cancer in infertile women undergoing hysteroscopic endometrial polypectomy for endometrial polyps. A total of 1035 infertile patients who underwent office-based hysteroscopic polypectomy at Sugiyama Clinic Marunouchi between July 2011 and October 2015
M Sugimoto et al.
Biochemical pharmacology, 42(12), 2363-2368 (1991-11-27)
The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats. The intrapleural injection of carrageenin caused a marked increase in
Teruya Komatsu et al.
International journal of surgery (London, England), 12(9), 936-939 (2014-08-06)
Appropriate postoperative analgesia is crucial in fast-track surgery, which is a multimodal therapeutic strategy that aims toward enhanced postoperative recovery and shortened hospital stay. Paravertebral block (PVB) has been reported to be as effective as thoracic epidural blockade (TEB), but
C Sakamoto et al.
Alimentary pharmacology & therapeutics, 37(3), 346-354 (2012-12-12)
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed globally, their chronic use increases the risk of upper gastrointestinal (GI) damage. Cyclooxygenase-2-selective NSAIDs are considered to reduce this risk. Current guidelines in Japan recommend loxoprofen sodium (loxoprofen), a pro-drug in the
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