The stock solutions may be stored at -20 degrees C in aliquots. Long-term stability studies have not been performed. However, information found in published literature indicates that it is quite stable. Please see the link below to review one example.
https://pubmed.ncbi.nlm.nih.gov/18933/
I6504
(−)-Isoproterenol hydrochloride
≥98% (TLC), powder, β-adrenoceptor agonist
Synonyme(s) :
(−)-Isoprenaline hydrochloride, (−)-N-Isopropyl-L-noradrenaline hydrochloride, (R)-3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol hydrochloride
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About This Item
Formule linéaire :
3,4-(HO)2C6H3CH(OH)CH2NHCH(CH3)2·HCl
Numéro CAS:
Poids moléculaire :
247.72
Beilstein:
6077193
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Nom du produit
(−)-Isoproterenol hydrochloride,
Niveau de qualité
Pf
175 °C (dec.) (lit.)
Solubilité
soluble (50 mg/ml: H2O)
Température de stockage
−20°C
Chaîne SMILES
Cl[H].CC(C)NC[C@H](O)c1ccc(O)c(O)c1
InChI
1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
Clé InChI
IROWCYIEJAOFOW-MERQFXBCSA-N
Informations sur le gène
human ... ADRB2(154)
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Application
Actions biochimiques/physiologiques
β-adrenoceptor agonist; increases cytosolic cAMP.
Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.[3]
Notes préparatoires
This material can be dissolved in 50 mg/ml of H2O.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Certificats d'analyse (COA)
Lot/Batch Number
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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.
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Les clients ont également consulté
Seon Jin Lee et al.
Stem cells international, 2018, 7453161-7453161 (2018-12-05)
Cross talks between the renin-angiotensin system (RAS), sympathetic nervous system, and vascular homeostasis are tightly coordinated in hypertension. Angiotensin II (Ang II), a key factor in RAS, when abnormally activated, affects the number and bioactivity of circulating human endothelial progenitor
Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period
De Koster J, et al.
Journal of Dairy Science, 99(3), 2319-2328 (2016)
Anne-Marie Schönegge et al.
Nature communications, 8(1), 2169-2169 (2017-12-20)
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we combined in
Michael H Lai et al.
American journal of physiology. Heart and circulatory physiology, 307(9), H1327-H1338 (2014-08-31)
Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels play prominent roles in shaping muscle and neuronal excitability. In the cardiovascular system, BK channels promote vascular relaxation and protect against ischemic injury. Recently, inhibition of BK channels has been shown to lower
Acute Care Handbook for Physical Therapists, 414-414 (2008)
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is product I65is product I6504 stable if reconstituted, aliquoted, and then frozen at -20C?
1 réponse-
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Wie man das Produkt Isoproterenol-hydrochlorid #I6504 am besten? Und gibt es eine Konzentrationsangabe, bei der es sich am besten löst?
1 réponse-
To order this material, please navigate to the link https://www.sigmaaldrich.com/support/customer-support, click on "Pricing & Availability" under the Products Section with all the required information so that a member of the Customer Service team can reach out to assist further.
This material can be dissolved in 50 mg/ml of H2O.
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What can be used to make a solution of (-)-Isoproterenol hydrochloride, Product I6504?
1 réponse-
We test the solubility of (-)-Isoproterenol hydrochloride in water at a concentration of 50 mg/mL. Isoproterenol hydrochloride is also soluble in ethanol at 20 mg/mL.
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Can I use a brownish-pink solution of (-)-Isoproterenol hydrochloride, Product I6504?
1 réponse-
Aqueous solutions become pink to brownish-pink when exposed to air, and almost immediately so when made alkaline. This color change indicates degradation.
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How should (-)-Isoproterenol hydrochloride, Product I6504, be stored?
1 réponse-
(-)-Isoproterenol hydrochloride is a powder that needs to be stored at -20°C.
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What is the Department of Transportation shipping information for this product?
1 réponse-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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