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I4161

Sigma-Aldrich

Interleukin-2 from mouse

IL-2, recombinant, expressed in E. coli, carrier free

Synonyme(s) :

mIL-2, IL-2, T-cell growth factor

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About This Item

Numéro MDL:
MFCD00164816
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

mouse

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

≤0.2 ng/mL ED50

Qualité

endotoxin tested

Poids mol.

17.2 kDa

Conditionnement

pkg of 5X20 μg
pkg of 20 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

≤0.200ng/ml

Couleur

white

Numéro d'accès UniProt

P04351

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

mouse ... Il2(16183)

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Actions biochimiques/physiologiques

Interleukin-2 (IL-2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Forme physique

Lyophilized with no additives.

Reconstitution

Centrifuge vial prior to opening. Reconstitute the contents of the vial in water to a concentration range of 0.1-1.0 mg/mL.
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319,H335

Classification des risques

Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Journal of vascular surgery, 62(6), 1625-1631 (2014-07-22)
This study assessed the effect of cellular and humoral autoimmune response inhibition after immunization with β2-glycoprotein I (β2-GPI) and the effect of immunomodulation with interleukin (IL)-2 and IL-10 in the development of early atherosclerotic vascular lesion in a murine model.
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(15), 1688-1696 (2015-03-25)
The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. We conducted a phase I/II clinical study in which patients with
Fang-Ting Lu et al.
Journal of autoimmunity, 61, 62-72 (2015-06-15)
Thymic CD4(+) FoxP3(+) regulatory T (Treg) cells are critical for the development of immunological tolerance and immune homeostasis and requires contributions of both thymic dendritic and epithelial cells. Although B cells have been reported to be present within the thymus
Larisa Kizima et al.
PloS one, 9(4), e94547-e94547 (2014-04-18)
Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) may more effectively limit HIV incidence. Previously
Stefan G Tullius et al.
Nature communications, 5, 5101-5101 (2014-10-08)
CD4(+) T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD(+)) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4(+)IFNγ(+)IL-10(+) T cells
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