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I2778

Sigma-Aldrich

Interleukin-1α human

IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor

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About This Item

Numéro MDL:
MFCD00164814
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Qualité

endotoxin tested

Poids mol.

~17 kDa

Conditionnement

pkg of 2 and 10 μg

Technique(s)

cell culture | mammalian: suitable

Numéro d'accès UniProt

P01583

Température de stockage

−20°C

Informations sur le gène

human ... IL1A(3552)

Catégories apparentées

Description générale

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Application

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

Actions biochimiques/physiologiques

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

Forme physique

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

Remarque sur l'analyse

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Conseils de prudence

P261 - P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Romain Duroux et al.
International journal of cosmetic science, 44(6), 614-624 (2022-08-19)
A critical and often-overlooked factor that may give rise to dandruff and oily hair is the intrinsic quality of the scalp stratum corneum (SC), which is often unbalanced and susceptible to external aggressions. Addressing the inflammation element of unhealthy scalp
Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Ivo C J H Post et al.
Xenotransplantation, 20(1), 18-26 (2013-01-26)
Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular
Peleg Rider et al.
Seminars in immunology, 25(6), 430-438 (2013-11-05)
Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is
Niklas Palmqvist et al.
Journal of inflammation (London, England), 13, 20-20 (2016-06-25)
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects and safety concerns associated with these agents restrict their use, and new, safe treatment
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Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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