H4914

Honokiol

≥98% (HPLC), powder

• Synonyme(s) : 5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100
• Formule empirique (notation de Hill): C₁₈H₁₈O₂
• Numéro CAS: 35354-74-6
• Poids moléculaire : 266.33
• Numéro MDL: MFCD00016674
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724501
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Solubilité: DMSO: 36 mg/mL
• Spectre d'activité de l'antibiotique: Gram-positive bacteria; neoplastics
• Mode d’action: DNA synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
• Clé InChI: FVYXIJYOAGAUQK-UHFFFAOYSA-N

Description

Description générale

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Application

Honokiol has been used:

• to study its effects on plasmid hSirt3^102-399 deacetylation activity
• as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
• to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
• for intracerebroventricular (ICV) cannulation

Actions biochimiques/physiologiques

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H318,H411
• Conseils de prudence: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Classification des risques: Aquatic Chronic 2 - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves