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H1015

Sigma-Aldrich

25-Hydroxycholesterol

≥98%

Synonyme(s) :

5-Cholestene-3β,25-diol

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10 MG
274,00 €
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601,00 €
100 MG
1 275,00 €

274,00 €

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Changer de vue
10 MG
274,00 €
25 MG
601,00 €
100 MG
1 275,00 €

About This Item

Formule empirique (notation de Hill) :
C27H46O2
Numéro CAS:
2140-46-7
Poids moléculaire :
402.65
Beilstein:
3161259
Numéro MDL:
MFCD00057815
Code UNSPSC :
41141804
eCl@ss :
39023139
ID de substance PubChem :
329815150
Nomenclature NACRES :
NA.77

274,00 €

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Devis pour commande en gros

Source biologique

synthetic (organic)

Essai

≥98%

Forme

powder

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C

InChI

1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1

Clé InChI

INBGSXNNRGWLJU-ZHHJOTBYSA-N

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Catégories apparentées

Application

25-Hydroxycholesterol was used to treat mouse neuroblastoma cells to activate the ABCA1 signaling[1] and in studies related to fatty acid metabolism.[2][3]

Actions biochimiques/physiologiques

25-Hydroxycholesterol is a side-chain oxysterol that reportedly triggers activation of a number of cholesterol molecules. This triggers their movement from cell membrane to the endoplasmic reticulum (ER).[4] 25-Hydroxycholesterol affects the immune system and has a key role in the pathogenesis of atherosclerosis.[5]
Suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). 25-Hydroxycholesterol induces apoptosis through down-regulation of Bcl-2 expression and activation of caspases.

Notes préparatoires

A stock solution of 25-Hydroxycholesterol may be prepared in ethanol and dissolved in cell culture medium to give a final concentration of 1 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000429130
0000429130
0000402240
0000402237
0000395043

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Consulter la Bibliothèque de documents

25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells
Koarai A et al
Respiratory Research, 13, doi: 10-doi: 10 (2012)
Ulf Diczfalusy
Biochimie, 95(3), 455-460 (2012-06-27)
The oxysterol 25-hydroxycholesterol is a widely used compound displaying an array of pharmacological actions in in vitro systems and cell based experimental systems. In spite of the frequent use of this compound over the last few decades and a large number
Alastair G Kerr et al.
The Journal of pharmacology and experimental therapeutics, 361(3), 417-428 (2017-04-01)
Hypercholesterolemia remains one of the leading risk factors for the development of cardiovascular disease. Many large double-blind studies have demonstrated that lowering low-density lipoprotein (LDL) cholesterol using a statin can reduce the risk of having a cardiovascular event by approximately
Marina Parra-Robert et al.
Biomolecules, 9(9) (2019-09-01)
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related
Brett N Olsen et al.
Biophysical journal, 100(4), 948-956 (2011-02-16)
Side-chain oxysterols are enzymatically generated oxidation products of cholesterol that serve a central role in mediating cholesterol homeostasis. Recent work has shown that side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), alter membrane structure in very different ways from cholesterol, suggesting a
Afficher tous les articles scientifiques apparentés

Articles

Cholesterol Biosynthesis Regulation

Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.

Questions

1–5 sur 5 questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the solubility and solution storage conditions of (2-Hydroxypropyl)-β-cyclodextrin

    1 réponse

    1. (2-Hydroxypropyl)-β-cyclodextrin is soluble in water up to 100 mM, and the recommended storage conditions for the prepared solution are at -20°C. It is advisable to use the solution within 1 month once prepared.

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  4. What is the solubility of 25-Hydroxycholesterol, H1015 (CAS number: 2140-46-7), and what are the storage conditions for the prepared solution?

    1 réponse

    1. The solubility of 25-Hydroxycholesterol, H1015 (CAS number: 2140-46-7), is up to 20 mM in ethanol. The recommended storage for prepared solutions is at -20°C, and they should be used within 1 month of preparation.

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  5. 안녕하세요. Stock 농도는 어떻게 만들어야할까요?

    1 réponse

    1. This product is soluble at 8 mg/mL in ethanol. The stock solution may then be diluted further with culture medium or workiing buffer.

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