E7879

β-Estradiol 17-acetate

≥99%

• Synonyme(s) : 1,3,5(10)-estratriène-3,17β-diol 17-acétate, 3,17β-dihydroxy-1,3,5(10)-estratriène 17-acétate
• Formule empirique (notation de Hill) : C₂₀H₂₆O₃
• Numéro CAS: 1743-60-8
• Poids moléculaire : 314.42
• Beilstein: 2625732
• Numéro MDL: MFCD00056537
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894658
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Essai: ≥99%
• Forme: powder
• Solubilité: chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: CC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
• InChI: 1S/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1
• Clé InChI: QAHOQNJVHDHYRN-SLHNCBLASA-N

Description

Application

β-Estradiol 17-acetate has been used in body burden analyses, to study the effect of triclosan on an estuarine fish.[1]

Actions biochimiques/physiologiques

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity.[2] β-Estradiol maintains bone homeostasis, and hence is preferred for osteoporosis therapy.[3] 17-β-Estradiol is the most active estrogen generated in our body.[4] During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.[5]

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H360FD,H410
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classification des risques: Aquatic Chronic 1 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges