This product is tested for solubility at 10mg/mL in 0.2M Tris, pH 8.8, resulting in a turbid solution. A clear solution has not been obtained. A further purified, salt-free version of this material, product E6527, produces a clear to hazy solution in water at 10mg/mL. Please see the link below to review a sample or lot-specific Certificate of Analysis for this item:
https://www.sigmaaldrich.com/product/sigma/e6527#product-documentation
E1625
Elastin from bovine neck ligament
powder
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157,00 €
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271,00 €
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5 G
157,00 €
10 G
271,00 €
About This Item
Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61
Produits recommandés
Source biologique
bovine neck ligament
Niveau de qualité
Forme
powder
Numéro d'accès UniProt
Température de stockage
2-8°C
Chaîne SMILES
N1([C@@H](CCC1)C(=O)NC)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)[C@H](CC)C)C(C)C
InChI
1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
Clé InChI
DPUYCSDGMSDKKV-MKBYFEBXSA-N
Informations sur le gène
cow ... ELN(280781)
Application
Elastin is a structural protein which has been used in studies of Chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.
Actions biochimiques/physiologiques
Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Certificats d'analyse (COA)
Lot/Batch Number
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
H M Morrison et al.
Biochimica et biophysica acta, 1430(2), 179-190 (1999-03-20)
Solubilization of elastin by human leukocyte elastase (HLE) cannot be analyzed by conventional kinetic methods because the biologically relevant substrate is insoluble and the concentration of enzyme-substrate complex has no physical meaning. We now report quantitative measurements of the binding
N Vyavahare et al.
The American journal of pathology, 155(3), 973-982 (1999-09-17)
Elastin, an abundant structural protein present in the arterial wall, is prone to calcification in a number of disease processes including porcine bioprosthetic heart valve calcification and atherosclerosis. The mechanisms of elastin calcification are not completely elucidated. In the present
Isabella C P Rodrigues et al.
Artificial organs, 45(5), E113-E122 (2020-11-11)
Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists
Katsuhiko Tsuchida et al.
Scientific reports, 10(1), 21667-21667 (2020-12-12)
Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has
Yueying Zhu et al.
Virulence, 13(1), 1221-1241 (2022-07-27)
Bacterial pathogens have a critical impact on aquaculture, a sector that accounts for half of the human fish consumption. Flavobacterium psychrophilum (phylum Bacteroidetes) is responsible for bacterial cold-water disease in salmonids worldwide. The molecular factors involved in host invasion, colonization
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Hello, I was wondering if you can recommend any procedures for dissolving the powder? I have tried in 0.2M Tris pH8.8 at 10mg/mL, as recommend in literature without success.
1 réponse-
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