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D8893
Dexaméthasone
powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)
Synonyme(s) :
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-méthylpregna-1,4-diène-3,20-dione, 9α-Fluoro-16α-méthyl-11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione, 9α-Fluoro-16α-méthylprednisolone, Prednisolone F
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1 MG
123,00 €
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1 MG
123,00 €
About This Item
Formule empirique (notation de Hill) :
C22H29FO5
Numéro CAS:
Poids moléculaire :
392.46
Beilstein:
2066651
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352209
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Produits recommandés
Source biologique
synthetic (organic)
Niveau de qualité
Stérilité
γ-irradiated
Gamme de produits
BioXtra
Essai
≥80% (HPLC)
Forme
powder
Puissance
4-500 ng/mL
Technique(s)
cell culture | mammalian: suitable
Pf
262-264 °C (lit.)
Solubilité
ethanol: 1 mL/vial, clear
Conditions d'expédition
ambient
Température de stockage
2-8°C
Chaîne SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Clé InChI
UREBDLICKHMUKA-CXSFZGCWSA-N
Informations sur le gène
human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)
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Application
Actions biochimiques/physiologiques
Agent anti-inflammatoire du type glucocorticoïde
Agent anti-inflammatoire du type glucocorticoïde. Régule la survie, la croissance et la différenciation des lymphocytes T. Inhibe l′induction de l′oxyde nitrique synthase.
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).[4] Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins.[5] It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.
Forme physique
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Reconstitution
To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Repr. 1B
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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What is the Department of Transportation shipping information for this product?
1 réponse-
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What is the solubility of Product D8893, Dexamethasone, in ethanol?
1 réponse-
The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.
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What is the best way to dissolve Product D8893, Dexamethasone?
1 réponse-
The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).
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How do the dexamethasone products D8893 and the D4902 compare?
1 réponse-
They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.
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What is the solubility of Product D8893, Dexamethasone, in DMSO?
1 réponse-
The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.
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What solution stability information do you have available for Product D8893, Dexamethasone?
1 réponse-
We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.
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