A7111

Acepromazine maleate

≥98% (HPLC)

• Synonyme(s) : Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt
• Formule empirique (notation de Hill) : C₁₉H₂₂N₂OS · C₄H₄O₄
• Numéro CAS: 3598-37-6
• Poids moléculaire : 442.53
• Numéro CE : 222-748-9
• Numéro MDL: MFCD00082473
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770915
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: yellow
• Solubilité: H₂O: >10 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O
• InChI: 1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• Clé InChI: FQRHOOHLUYHMGG-BTJKTKAUSA-N

Description

Application

Acepromazine maleate has been used:

• as a component of anesthesia cocktail to test its effects on behavioral changes in rats[1]
• as a component of anesthesia cocktail to study its effects on lung resistance of rats[2]
• as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells[3]

Actions biochimiques/physiologiques

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.

Atypical neuroleptic.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H336
• Conseils de prudence: P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable