A6955
Angiogenin human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonyme(s) :
ANG
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50 μG
599,90 €
599,90 €
Tarif857,00 €Économiser 30 %Date d'expédition estimée le17 avril 2025
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50 μG
599,90 €
About This Item
599,90 €
Tarif857,00 €Économiser 30 %Date d'expédition estimée le17 avril 2025
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in E. coli
Essai
≥97% (SDS-PAGE)
Forme
lyophilized powder
Poids mol.
14.4 kDa
Conditionnement
pkg of 50 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Technique(s)
cell culture | mammalian: suitable
Impuretés
endotoxin, tested
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... ANG(283)
Description générale
Angiogenin is a secreted growth factor. It is localized in the tissue fluids such as plasma, amniotic fluid, cerebrospinal fluid and tumor microenvironment.[1]
Application
Actions biochimiques/physiologiques
Angiogenin plays a role in several biological functions such as tumorigenesis, innate immunity, neuroprotection. It also plays a role in reproduction, regeneration of damaged tissues and neovascularization.[1]
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Remarque sur l'analyse
The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.[4]
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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D J Strydom
Cellular and molecular life sciences : CMLS, 54(8), 811-824 (1998-10-07)
The angiogenic and other biological functions of the angiogenins, members of the pancreatic RNase superfamily of proteins, are reviewed in the context of their primary and tertiary structures. The ribonucleolytic activity and interactions with the placental ribonuclease inhibitor have seen
Human angiogenin lacks specific antimicrobial activity
Avdeeva, Svetlana V, et al.
Current Microbiology, 53(6), 477-478 (2006)
J Badet
Pathologie-biologie, 47(4), 345-351 (1999-06-18)
Angiogenin is a heparin-binding 14 kDa plasma protein with angiogenic and ribonucleolytic activity. Although its structural features have been extensively studied, an understanding of its physiological role and of how its properties are expressed continues to elude researchers. This article
Evaluation of angiogenesis in diabetic lower limb wound healing using a natural medicine: A quantitative approach
Barui A, et al.
Wounds : a compendium of clinical research and practice, 6, 26-33 (2014)
Three decades of research on angiogenin: a review and perspective
Sheng J and Xu Z
Acta biochimica et biophysica Sinica, 48(5), 399-410 (2016)
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