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A4730

Sigma-Aldrich

Amthamine dihydrobromide

≥98% (HPLC), solid

Synonyme(s) :

2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide

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About This Item

Formule empirique (notation de Hill):
C6H11N3S · 2HBr
Numéro CAS:
142457-00-9
Poids moléculaire :
319.06
Numéro MDL:
MFCD00673891
Code UNSPSC :
12352200
ID de substance PubChem :
24890905
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Couleur

off-white

Solubilité

H2O: 27 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Br[H].Br[H].Cc1nc(N)sc1CCN

InChI

1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H

Clé InChI

XFXNNOPUDSFVJE-UHFFFAOYSA-N

Application

Amthamine dihydrobromide is a histamine H2 receptor agonist. Amthamine dihydrobromide has been used to study the effect of mast cells on T regulatory cell function.

Actions biochimiques/physiologiques

Amthamine dihydrobromide is a H2 histamine receptor agonist. Amthamine dihydrobromide, similar to histamine, inhibits H2 receptor-mediated eosinophil peroxidase (EPO) release with IC50 = 0.4 μM; a weak antagonist at H3 and shows no activity at H1 receptors.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

G Coruzzi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(1), 77-81 (1993-07-01)
The new histamine H2 receptor agonist amthamine, [2-amino-5-(2-aminoethyl)-4-methylthiazole], was tested for its activity on gastric acid secretion in different in vivo and in vitro experimental models. Amthamine induced a dose-related increase in acid secretion both in conscious cats with a
E Poli et al.
Agents and actions, 40(1-2), 44-49 (1993-09-01)
The cardiac activity of the novel histamine H2-receptor agonist amthamine was investigated in a variety of isolated heart preparations from guinea pigs and humans and in the isolated rabbit aorta. Amthamine caused an increase in the sinus rate of spontaneously
J C Eriks et al.
Molecular pharmacology, 44(4), 886-894 (1993-10-01)
Recently we developed amthamine [2-amino-5-(2-aminoethyl)-4-methylthiazole]. This cyclic analogue of dimaprit proved to be the most potent and selective histamine H2 receptor agonist of a series of substituted 4- or 5-(2-aminoethyl)thiazoles. Quantum chemical studies on histamine (N pi-H tautomer), dimaprit, and
J C Eriks et al.
Journal of medicinal chemistry, 35(17), 3239-3246 (1992-08-21)
It is well known that both histamine and dimaprit show moderate histamine H2-receptor agonistic activities on the guinea pig right atrium. Quantum chemical calculations on these two compounds showed similarities in electron distributions and molecular electrostatic potentials (MEP's), which could
Cardiac effects of amthamine: a new histamine H2-receptor agonist.
G Coruzzi et al.
European journal of clinical investigation, 25 Suppl 1, 27-28 (1995-03-01)
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