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C0750

Sigma-Aldrich

Caféine

powder, ReagentPlus®

Synonyme(s) :

1,3,7-triméthylxanthine

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5 G
35,10 €
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71,20 €
500 G
197,00 €
1 KG
336,00 €

35,10 €

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5 G
35,10 €
100 G
71,20 €
500 G
197,00 €
1 KG
336,00 €

About This Item

Formule empirique (notation de Hill):
C8H10N4O2
Numéro CAS:
58-08-2
Poids moléculaire :
194.19
Beilstein:
17705
Numéro CE :
200-362-1
Numéro MDL:
MFCD00005758
Code UNSPSC :
12352210
ID de substance PubChem :
24277682
Nomenclature NACRES :
NA.21

35,10 €

En stockDétails

Devis pour commande en gros

Niveau de qualité

200

Gamme de produits

ReagentPlus®

Forme

powder

Pf

234-236.5 °C (lit.)

Solubilité

H2O: 15 mg/mL

Chaîne SMILES 

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

Clé InChI

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Informations sur le gène

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE4B(5142) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290) , Adora2a(25369)

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Description générale

Caffeine is a widely ingested pharmacologically active substance. It belongs to the class of methylxanthines.[1] It is a naturally occurring alkaloid found in coffee, cocoa and other plants. Caffeine might be associated with osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances.[2] Caffeine is used to treat orthostatic hypotension,[3] bronchopulmonary dysplasia and apnea of prematurity (AOP).[4]

Application

Caffeine has been used:
  • to study its impact on the fluorescence of Petunia nuclei[5]
  • as a stimulant to induce c-fos expression in rodents[6]
  • as a component of defined media for the development of bovine oocytes in vitro[7]

Attention

Keep tightly sealed.

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000419557
0000419557
0000419556
0000419556
0000407034

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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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A simple method for immunohistochemical staining of zebrafish brain sections for c-fos protein expression
Chatterjee D, et al.
Zebrafish, 12(6), 414-420 (2015)
Effects of caffeine and chlorogenic acid on propidium iodide accessibility to DNA: consequences on genome size evaluation in coffee tree
Noirot M, et al.
Annals of Botany, 92(2), 259-264 (2003)
Apnea of prematurity: from cause to treatment
Zhao J, et al.
European Journal of Pediatrics, 170(9), 1097-1105 (2011)
Metabolic effects of spices, teas, and caffeine
Westerterp-Plantenga M, et al.
Physiology & Behavior, 89(1), 85-91 (2006)
L Keskintepe et al.
Biology of reproduction, 55(2), 333-339 (1996-08-01)
The objective was to establish an in vitro system in which bovine oocytes can be matured, fertilized, and cultured up to the blastocyst stage without support of serum, BSA, or somatic cells. Media consisted of modified tissue culture medium 199
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Protocoles

Protocol for In-vitro Permeation Testing Using Strat-M® Membranes

Strat-M® synthetic membrane mimics the human skin for In-vitro permeation testing (IVPT) of topical and transdermal formulations

Questions

1–3 sur 3 questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How do I make a stock solution of caffeine catalog number C0750?

    1 réponse

    1. The stock solutions of caffeine are prepared by dissolving the appropriate amounts of caffeine in distilled water, ethanol, methanol, or chloroform. This product is tested for solubility at 15 mg/mL in water. Please note that the choice of solvent and concentration would depend on the specific application requirements.

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