A2487

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

• Synonyme(s) : Trimethoprim-Sulfamethoxazole, TMP-SMX
• Formule empirique (notation de Hill): C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• Numéro CAS: 8064-90-2
• Poids moléculaire : 1556.71
• Code UNSPSC : 51102829
• Nomenclature NACRES : NA.85

Propriétés

• Forme: liquid
• Niveau de qualité: 200
• Concentration: 100 mg/mL in DMSO
• Couleur: colorless to faint yellow
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• Mode d’action: DNA synthesis | interferes
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• Clé InChI: WZRJTRPJURQBRM-UHFFFAOYSA-N

Description

Application

Cotrimoxazole has been used as an antimicrobial agent.

Actions biochimiques/physiologiques

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Conditionnement

1ml

Notes préparatoires

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361fd,H412
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Aquatic Chronic 3 - Repr. 2
• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable