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95144

Sigma-Aldrich

Rétinol

BioXtra, ≥97.5% (HPLC), ~3100 U/mg

Synonyme(s) :

Alcool de vitamine A, Axérophtol, Vitamine A, Vitamine A1, tout-trans-3,7-diméthyl-9-(2,6,6-triméthyl-1-cyclohexén-1-yl)-2,4,6,8-nonatétraén-1-ol

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250 MG
136,00 €
1 G
456,00 €

136,00 €

Disponible pour expédition le10 avril 2025Détails

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250 MG
136,00 €
1 G
456,00 €

About This Item

Formule empirique (notation de Hill) :
C20H30O
Numéro CAS:
68-26-8
Poids moléculaire :
286.45
Beilstein:
403040
Numéro CE :
200-683-7
Numéro MDL:
MFCD00001552
Code UNSPSC :
12352205
eCl@ss :
34058018
ID de substance PubChem :
57653654
Nomenclature NACRES :
NA.28

136,00 €

Disponible pour expédition le10 avril 2025Détails

Devis pour commande en gros

Source biologique

synthetic

Gamme de produits

BioXtra

Essai

≥97.5% (HPLC)

Forme

(Powder or Powder with Lumps)

Activité spécifique

~3100 U/mg

Durée de conservation

limited shelf life

Couleur

faint yellow to very dark yellow

Pf

56-61 °C
61-63 °C (lit.)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

Clé InChI

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

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Catégories apparentées

Description générale

Retinol or vitamin A alcohol is the main circulating form of vitamin A.[1]

Application

Retinol has been used:
  • as a standard in peak identification and quantification in reverse phase HPLC[2]
  • as a standard to estimate the concentration of vitamin A[3]
  • to study the inhibitory effect of retinol on murine norovirus (MNV) replication in murine RAW 264.7 cells[4]
  • as a component in the reaction mixture for the lecithin:retinol acyltransferase (LRAT) assay[5]

Actions biochimiques/physiologiques

It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid.[1]
Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Définition de l'unité

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H317,H319,H360FD,H413

Classification des risques

Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCM5486
BCCL8551
BCCM6917
0000393018
0000393018

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Vitamin A water-miscible 1 ml = 200,000 I.U. for oral use, EMPROVE® ESSENTIAL, Ph. Eur., BP

SAFC

5.00849

Vitamin A

Rétinyl-palmitate Type IV, ~1,800,000 USP units/g, oil

Sigma-Aldrich

R3375

Rétinyl-palmitate

Retinyl propionate ≥98.0% (sum of isomers, HPLC), ~2500 U/mg

Sigma-Aldrich

87809

Retinyl propionate

vibrant-m

R0290000

Retinol esters

9-cis-Retinal vitamin A analog

Sigma-Aldrich

R5754

9-cis-Retinal

Retinyl acetate analytical standard

Supelco

46958

Retinyl acetate

Retinyl acetate BioReagent, suitable for cell culture

Sigma-Aldrich

R0635

Retinyl acetate

Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models
Quadro L, et al.
Molecular Aspects of Medicine, 24(6), 421-430 (2003)
Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome
Lee H and Ko G
Scientific reports, 25835-25835 (2016)
Retinyl palmitate does not have an adjuvant effect on the antibody response of chicks to keyhole limpet hemocyanin regardless of vitamin A status
Livingston KA and Klasing KC
Poultry Science, 90(5), 965-970 (2011)
Heetae Lee et al.
Scientific reports, 6, 25835-25835 (2016-05-18)
The effect and underlying mechanism of vitamin A on norovirus infection are largely unknown. This study aimed to investigate how vitamin A administration affects the gut microbiome after norovirus infection. Here, we demonstrate that treatment with either retinol or retinoic
Responses of blood metabolites and proteins to different vitamin A levels in Korean native steers.
Wang T, et al.
Pakistan journal of botany, 34(4) (2014)
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Protocoles

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

Questions

1–2 sur 2 questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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