47612

Folinic acid calcium salt hydrate

BioXtra, ≥99.0% (HPLC)

• Synonyme(s) : 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H₄PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt
• Formule empirique (notation de Hill) : C₂₀H₂₁CaN₇O₇ · xH₂O
• Numéro CAS: 1492-18-8
• Poids moléculaire : 511.50 (anhydrous basis)
• Beilstein: 5723924
• Numéro MDL: MFCD00149463
• Code UNSPSC : 12352106
• ID de substance PubChem : 24871209
• Nomenclature NACRES : NA.28

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Gamme de produits: BioXtra
• Essai: ≥99.0% (HPLC)
• Forme: powder or crystals
• Technique(s): cell culture | mammalian: suitable
• Couleur: white to faint yellow
• Pf: 240-250 °C
• Application(s): cell analysis
• Chaîne SMILES: [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• Clé InChI: KVUAALJSMIVURS-ZEDZUCNESA-L

Description

Description générale

Calcium salt of the (6R,S)-mixture of diastereomers of 5-formyl-5,6,7,8-tetrahydrofolate.

Folinic acid, also called as calcium leucovorin, is usually available as an amorphous powder and lacks odor.[1] This activated form of vitamin B₉[2] is off-white to light beige in color.[1] Folic acid (FA) is a water-soluble vitamin. Folinic acid is the 5-formyl derivative of tetrahydrofolic acid and is the reduced form of folic acid.[3]

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Folinic acid calcium salt hydrate has been used in the preparation of topical 1% and 2.5% folinic acid creams for use in wound healing studies.[4] It has also been used as a component in the chemically defined-Chinese hamster ovary medium (CD-CHO) to culture CHO DUKX B11.[5]

Actions biochimiques/physiologiques

Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions.[2] It helps in improving wound healing in rats.[4] Folinic acid plays a major role in children with autism to enhance verbal communication.[6]

Autres remarques

Review[7]

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H317,H319,H334,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves