413A-1

GLUT3 Rabbit Polyclonal Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC (p)
• Citations: 2

Propriétés

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: Ig fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (413A-14), vial of 0.5 mL concentrate (413A-15), bottle of 1.0 mL predilute (413A-17), vial of 1.0 mL concentrate (413A-16), bottle of 7.0 mL predilute (413A-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• control: embryonal carcinoma, yolk sac tumor
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: membranous
• Gene Information: human ... SLC2A3(6515)

Description

General description

Glucose transporter membrane 3 (GLUT3) is known as a solute carrier family 2 (facilitated glucose transporter) member 3 and represents a membrane bound glucose transporter. In one study scientists, using immunoprecipitation and western blot technologies, detected GLUT3 expression in spermatozoa of testis and brain but not in other types of tissue.[1] In-house research via immunohistochemistry confirmed GLUT3 expression in testis/spermatozoa, but no GLUT3 was detected in brain. In a study conducted by Howitt BE et. al. anti-GLUT3 demonstrated membranous staining of seminoma cells in 44 cases (65%) of total 67 specimens.[2] In addition, anti-GLUT3 labeled embryonal carcinoma (20/20) and yolk sac tumor (8/8) with 100% sensitivity.[2]GLUT3 is not expressed in non-germ cell tumors such as leydig cell tumor and adenomatoid tumor.[2]Spermatocytic seminoma, choriocarcinoma, and immature teratoma are also negative for GLUT3.[2] Therefore, anti-GLUT3 is a very useful IHC marker to include in a panel for identification of germ cell tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

GLUT3 Positive Control Slides, Product No. 413S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany