00541

Ruthenium Red

for microscopy, 85.0-115.0% (calc. on dry basis, AT)

• Synonyme(s) : Ammoniated ruthenium oxychloride
• Formule linéaire : [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• Numéro CAS: 11103-72-3
• Poids moléculaire : 786.35
• Numéro C.I. (Colour Index): 77800
• Numéro MDL: MFCD00011479
• Code UNSPSC : 12171500
• ID de substance PubChem : 329747091
• Nomenclature NACRES : NA.47

Propriétés

• Qualité: for microscopy
• Niveau de qualité: 100
• Essai: 85.0-115.0% (calc. on dry basis, AT)
• Forme: powder
• Impuretés: ~5% water
• Solubilité: water: 10 mg/mL, clear to turbid
• εmax: ≥150 at 529-539 nm
• Adéquation: suitable for microscopy
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]; N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
• InChI: 1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
• Clé InChI: ZXYSDUPLHOJIOR-UHFFFAOYSA-H

Description

Description générale

Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.

Application

Inhibits mitochondrial Ca²⁺ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.

Actions biochimiques/physiologiques

Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable