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Y0000450

Ketamine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(±)-Ketamine hydrochloride, (±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride

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About This Item

Formule empirique (notation de Hill):
C13H16ClNO · HCl
Numéro CAS:
1867-66-9
Poids moléculaire :
274.19
Numéro MDL:
MFCD00051420
Code UNSPSC :
12352116
ID de substance PubChem :
329830963
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

ketamine

Fabricant/nom de marque

EDQM

Contrôle du médicament

regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CNC1(CCCCC1=O)c2ccccc2Cl

InChI

1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

Clé InChI

VCMGMSHEPQENPE-UHFFFAOYSA-N

Informations sur le gène

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ketamine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H336

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Paulo R Shiroma et al.
The international journal of neuropsychopharmacology, 17(11), 1805-1813 (2014-06-26)
The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive performance and change in
Yongzhi Wang et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H540-H547 (2014-12-17)
Abdominal sepsis is associated with significant changes in systemic inflammation and coagulation. The purpose of the present study was to examine the role of peripheral blood monocytes for systemic coagulation, including thrombin generation and consumption of coagulation factors. Abdominal sepsis
Jana Sawynok
Anesthesia and analgesia, 119(1), 170-178 (2014-06-20)
Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve
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Shock (Augusta, Ga.), 42(4), 343-349 (2014-07-01)
Systemic inflammatory response syndrome and severe infections are associated with major derangements in the coagulation system. The purpose of this study was to examine the dynamic alterations in thrombin generation in abdominal sepsis. Abdominal sepsis was induced by cecal ligation
José Luis Calvo-Guirado et al.
Clinical oral investigations, 18(5), 1495-1505 (2013-10-19)
This study presents a biomechanical comparison of bone response to commercially pure titanium screws with four different types of surface topographies placed in the tibial metaphysis of 30 rabbits. One hundred twenty implants were tested double-blinded: (a) blasted, acid-etched, and
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