PHR1158
Benzocaine
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
4-Aminobenzoic acid ethyl ester, Ethyl 4-aminobenzoate
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About This Item
Formule empirique (notation de Hill):
C9H11NO2
Numéro CAS:
Poids moléculaire :
165.19
Numéro Beilstein :
638434
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
certified reference material
pharmaceutical secondary standard
Niveau de qualité
Agence
traceable to USP 1054000
Famille d'API
benzocaine
CofA (certificat d'analyse)
current certificate can be downloaded
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Application(s)
pharmaceutical (small molecule)
Format
neat
Température de stockage
2-30°C
Chaîne SMILES
CCOC(=O)c1ccc(N)cc1
InChI
1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
Clé InChI
BLFLLBZGZJTVJG-UHFFFAOYSA-N
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Description générale
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzocaine is an ester-type local anesthetic, able to induce pain relief. It is used extensively in topical, mucosal and dermal formulations.
Benzocaine is an ester-type local anesthetic, able to induce pain relief. It is used extensively in topical, mucosal and dermal formulations.
Application
Benzocaine may be used as a pharmaceutical reference standard for the determination of the analyte in bioadhesive gel, pharmaceutical formulations and channel catfish tissues by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Remarque sur l'analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Autres remarques
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
Note de bas de page
To see an example of a Certificate of Analysis for this material enter LRAA6506 in the slot below. This is an example certificate only and may not be the lot that you receive.
Produits recommandés
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Skin Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
233.6 °F
Point d'éclair (°C)
112 °C
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Les clients ont également consulté
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
Perez-Lozano P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(5), 920-927 (2005)
Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation.
Gigante B, et al.
Journal of Chromatography A, 549(5), 217-220 (1991)
A Szoke et al.
Journal of pharmaceutical and biomedical analysis, 16(1), 69-75 (1998-02-03)
Methods for extraction and gradient HPLC quantification were developed for benzocaine (BZ) and three of its metabolites to be used in conjunction with a reverse isotope technique. The metabolites were p-aminobenzoic acid (PABA), acetyl-p-aminobenzoic acid (AcPABA) and acetylbenzocaine (AcBZ). The
Methemoglobinemia: a complication after fiberoptic orotracheal intubation with benzocaine spray. A case report.
F D Ellis et al.
The Journal of bone and joint surgery. American volume, 77(6), 937-939 (1995-06-01)
L A Linares et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 18(3), 267-269 (1990-07-01)
Methemoglobinemia is a condition in which more than 2% of the hemoglobin of the blood has been oxidized to the ferric form, a molecule which is incapable of binding oxygen or carbon dioxide. Clinically, the patient appears lethargic, cyanotic, and
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