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B0600000

Benzocaine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-Aminobenzoic acid ethyl ester, Ethyl 4-aminobenzoate

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About This Item

Formule empirique (notation de Hill):
C9H11NO2
Numéro CAS:
94-09-7
Poids moléculaire :
165.19
Numéro Beilstein :
638434
Numéro MDL:
MFCD00007892
Code UNSPSC :
41116107
ID de substance PubChem :
329773120
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

benzocaine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

CCOC(=O)c1ccc(N)cc1

InChI

1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3

Clé InChI

BLFLLBZGZJTVJG-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzocaine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1054000

Benzocaine, United States Pharmacopeia (USP) Reference Standard

1019767

Aminobenzoate sodium, United States Pharmacopeia (USP) Reference Standard

1265300

Ethyl 4-nitrobenzoate, United States Pharmacopeia (USP) Reference Standard

PHR2094

Diethylamino Hydroxybenzoyl Hexyl Benzoate, Pharmaceutical Secondary Standard; Certified Reference Material

42263

Ethyl 4-formamidobenzoate, reference material

42051

Ethyl 4-[(2-acetyloxybenzoyl)amino]benzoate, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9020

2-Aminobenzyl alcohol, reference material

PHR9025

Methyl 4-aminobenzoate, reference material

PHR9030

N-Acetylbenzocaine, reference material

PHR2225

Ethyl 4-Nitrobenzoate, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

233.6 °F

Point d'éclair (°C)

112 °C

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Certificats d'analyse (COA)

Lot/Batch Number

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L F Rodriguez et al.
The Annals of pharmacotherapy, 28(5), 643-649 (1994-05-01)
To report a case of benzocaine-induced inethemoglobinemia and present a review of the related literature. An 83-year-old man received benzocaine topical anesthesia 600 mg prior to intubation for resection of a thyroid adenoma. The patient became severely cyanotic after induction
Stephan Warnke et al.
Journal of the American Chemical Society, 137(12), 4236-4242 (2015-03-12)
The immediate environment of a molecule can have a profound influence on its properties. Benzocaine, the ethyl ester of para-aminobenzoic acid that finds an application as a local anesthetic, is found to adopt in its protonated form at least two
Benzocaine-induced methemoglobinemia in the pediatric population.
Jodi Lehr et al.
Journal of pediatric nursing, 27(5), 583-588 (2012-07-24)
L A Linares et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 18(3), 267-269 (1990-07-01)
Methemoglobinemia is a condition in which more than 2% of the hemoglobin of the blood has been oxidized to the ferric form, a molecule which is incapable of binding oxygen or carbon dioxide. Clinically, the patient appears lethargic, cyanotic, and
H A Cooper
Southern medical journal, 90(9), 946-948 (1997-09-26)
Acute methemoglobinemia is a medical emergency that can rapidly become fatal. A substantial number of drugs, including topical preparations, can precipitate this condition. I report a rare example of severe, acute methemoglobinemia caused by oropharyngeal anesthesia with topical benzocaine spray
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