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COO/COA

I0775010

Isosorbide mononitrate

Name: Isosorbide mononitrate
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1,4:3,6-Dianhydro-D-glucitol 5-nitrate

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About This Item

Formule empirique (notation de Hill):

C₆H₉NO₆

Numéro CAS:

16051-77-7

Poids moléculaire :

191.14

Numéro CE :

240-197-2

Code UNSPSC :

41116107

Nomenclature NACRES :

NA.24

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Isosorbide dinitrate

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PHR1486

Isosorbide Solution

USP

1353102

Diluted Isosorbide Mononitrate

I0775020

Isosorbide 2-nitrate

USP

1353000

Diluted isosorbide dinitrate (25% mixture with lactose)

Sigma-Aldrich

D87201

2-Chloro-N,N-diethylethylamine hydrochloride

Supelco

PHR2558

1,4-Sorbitan

USP

1353113

Diluted Isosorbide Mononitrate Related Compound A

Sigma-Aldrich

CDS000404

2-[2-(Diethylamino)ethoxy]ethanol

Qualité

pharmaceutical primary standard

Famille d'API

isosorbide

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

Clé InChI

YWXYYJSYQOXTPL-SLPGGIOYSA-N

Catégories apparentées

Étalons de référence analytiques | Sigma-Aldrich

Étalons des instituts de métrologie et des pharmacopées

Matériaux de référence

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isosorbide mononitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

Mention d'avertissement

Danger

Mentions de danger

H228

Conseils de prudence

P210 - P240 - P241 - P280 - P370 + P378

Classification des risques

Flam. Sol. 1

Code de la classe de stockage

4.1A - Other explosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology.

Francesca Fabrizi et al.

Journal of enzyme inhibition and medicinal chemistry, 27(1), 138-147 (2011-08-06)

The clinically used sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor dorzolamide (DRZ), a new sulfonamide CA inhibitor also incorporating NO-donating moieties, NCX250, and isosorbide mononitrate (ISMN) (an NO-donating compound with no CA inhibitory properties) were investigated for their intraocular pressure

Pharmacokinetics of isosorbide mononitrate.

U W Abshagen

The American journal of cardiology, 70(17), 61G-66G (1992-11-27)

Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. The half-life is approximately 5 hours, the volume of distribution is 0.62

Can isosorbide mononitrate be useful in second trimester termination of pregnancies?

Athanasios Mousiolis et al.

Contraception, 88(1), 41-44 (2013-01-08)

Isosorbide mononitrate (IMN) administration is thought to enhance in the cervical ripening process. We sought to identify the clinical usefulness and safety of IMN administration for shortening the time to termination of the second trimester pregnancy procedures when used in

Huoxue Wentong Formula ameliorates myocardial infarction in rats through inhibiting CaMKII oxidation and phosphorylation.

Tiantian Liu et al.

Chinese medicine, 15, 3-3 (2020-01-16)

The Chinese medicine Huoxue Wentong Formula (HXWTF) was used to treat thoracic obstruction and angina pectoris in clinic, which has not been investigated in myocardial ischemia-induced apoptosis and angiogenic function. Here we aimed to investigate the roles of HXWTF in

Controlled and Localized Nitric Oxide Precursor Delivery From Chitosan Gels to Staphylococcus aureus Biofilms.

Sayeed Hasan et al.

Journal of pharmaceutical sciences, 106(12), 3556-3563 (2017-08-27)

Extracellular polymeric substances in bacterial biofilms reduce the penetration of antimicrobials and give rise to extreme recalcitrance and treatment challenges for many persistent biofilms and associated infections. Nitric oxide (NO) is a promising alternative to conventional antimicrobials but is challenging

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