I4883

Ibuprofen

≥98% (GC), powder, COX inhibitor

• Synonyme(s) : 2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
• Formule empirique (notation de Hill): C₁₃H₁₈O₂
• Numéro CAS: 15687-27-1
• Poids moléculaire : 206.28
• Numéro CE : 239-784-6
• Numéro MDL: MFCD00010393
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277715
• Nomenclature NACRES : NA.77

Propriétés

• product name: Ibuprofen, ≥98% (GC)
• Source biologique: synthetic (organic)
• Pureté: ≥98% (GC)
• Forme: powder
• Pf: 77-78 °C
• Solubilité: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• Chaîne SMILES: CC(C)Cc1ccc(cc1)C(C)C(O)=O
• InChI: 1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
• Clé InChI: HEFNNWSXXWATRW-UHFFFAOYSA-N
• Informations sur le gène: human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) ; rat ... Alox5(25290) , Ptgs1(24693)

Description

Description générale

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.

Application

Ibuprofen has been used:

• to study its vascular and pulmonary effects on neonatal lung development
• to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines
• in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties

Actions biochimiques/physiologiques

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P301 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves