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67667

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Acide kynurénique

analytical standard

Synonyme(s) :

Acide 4-hydroxyquinoline-2-carboxylique

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About This Item

Formule empirique (notation de Hill):
C10H7NO3
Numéro CAS:
492-27-3
Poids moléculaire :
189.17
Numéro Beilstein :
147451
Numéro CE :
207-751-5
Numéro MDL:
MFCD00006753
Code UNSPSC :
41116107

Qualité

analytical standard

Pureté

≥98.0% (HPLC)

Durée de conservation

limited shelf life, expiry date on the label

Pf

275 °C (dec.) (lit.)

Application(s)

clinical testing

Chaîne SMILES 

OC(=O)c1cc(O)c2ccccc2n1

InChI

1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

Clé InChI

HCZHHEIFKROPDY-UHFFFAOYSA-N

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Description générale

Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.

Application

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.

Produits recommandés

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCCF6732
BCCB2225

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Les clients ont également consulté

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L-Tryptophane reagent grade, ≥98% (HPLC)

Sigma-Aldrich

T0254

L-Tryptophane

Presence of kynurenic acid in food and honeybee products
Turski PM, et al.
Amino Acids, 36(1), 75-80 (2009)
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
Erhardt S, et al.
Neuroscience Letters, 313(1-2), 96-98 (2001)
Determination of kynurenic acid in human serum and its correlation with the concentration of certain amino acids
Fukushima T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 377(1-2), 174-178 (2007)
Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord
Ganong HA, et al.
Brain Research, 273(1), 170-174 (1983)
More rapid and sensitive method for simultaneous determination of tryptophan and kynurenic acid by HPLC
Lan-Gan P, et al.
Clinical Biochemistry, 42(4-5), 420-425 (2009)
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