ABT330
Anti-TSLP Antibody
from rabbit, purified by affinity chromatography
Synonyme(s) :
TSLP Antibody, Thymic stromal lymphopoietin
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
mouse, human
Technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TSLP(85480)
Description générale
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. TSLP is expressed in a number of tissues including heart, liver, and prostate.
Spécificité
This antibody recognizes the intermediate domain of TSLP.
Immunogène
Epitope: Intermediate domain
KLH-conjugated linear peptide corresponding to the intermediate domain of human TSLP.
Application
Detect Thymic stromal lymphopoietin using this rabbit polyclonal antibody, Anti-TSLP Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TSLP in human prostate cancer and heart tissues.
Immunofluorescence Analysis: A 20 μg/mL from a representative lot detected TSLP in human brain cells.
Immunofluorescence Analysis: A 20 μg/mL from a representative lot detected TSLP in human brain cells.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Qualité
Evaluated by Western Blotting in A20 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP in 15 µg of A20 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP in 15 µg of A20 cell lysate.
Description de la cible
~23 kDa observed. The calculated molecular weight of this protein is 18 kDa, but can be observed at ~23 kDa due to high glycosylation.
Forme physique
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Remarque sur l'analyse
Control
A20 cell lysate
A20 cell lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Kathleen M Buchheit et al.
The Journal of allergy and clinical immunology, 137(5), 1566-1576 (2015-12-23)
Prostaglandin (PG) D2 is the dominant COX product of mast cells and is an effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory disease (AERD). We evaluated the role of the innate cytokine thymic stromal lymphopoietin (TSLP) acting on
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Simon G Royce et al.
Clinical science (London, England : 1979), 130(23), 2151-2165 (2016-11-01)
Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling (AWR), which can develop independently of AI and contribute to irreversible airway obstruction. The present study compared the anti-remodelling
Eda Ustaoglu et al.
Indian journal of dermatology, 68(2), 170-177 (2023-06-05)
This study aims to investigate the anti-inflammatory effects of cinnamaldehyde in atopic dermatitis (AD) in the mouse model. Twenty-four mice were divided into four groups: Group A (control), group B [AD with no treatment (AD + NoTre)], group C [AD
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