676491

VEGF Inducer, GS4012

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

• Synonyme(s) : VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
• Formule empirique (notation de Hill) : C₁₄H₁₅NOS · xHCl
• Numéro CAS: 328073-92-3
• Poids moléculaire : 245.34 (free base basis)
• Numéro MDL: MFCD00550210
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.51

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white
• Solubilité: DMSO: 200 mg/mL; methanol: 50 mg/mL; water: soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: S(CCc2ccncc2)c1ccc(cc1)OC.Cl
• InChI: 1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H
• Clé InChI: CYZALCLQLHDAEC-UHFFFAOYSA-N

Description

Description générale

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable