5.09890

Benztropine

• Synonyme(s) : Benztropine, Benzatropine, Cogentin
• Formule empirique (notation de Hill): C₂₁H₂NO · xCH₄O₃S
• Numéro CAS: 132-17-2
• Poids moléculaire : 284.25 (free base basis)
• Numéro MDL: MFCD00074784
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Température de stockage: 2-8°C
• InChI: 1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
• Clé InChI: CPFJLLXFNPCTDW-STYNFMPRSA-N

Description

Description générale

A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC₅₀ = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Muscarinic M1/M3

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Toxic (F)

Autres remarques

Deshmukh, V.A, et al. 2013. Nature 502,327.
Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.

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Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H311 + H331
• Conseils de prudence: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable