5.08158

TGF-β

InSolution, ≥99%, 50 mM in DMSO, RI Kinase Inhibitor II, RepSox

• Synonyme(s) : InSolution TGF-β RI Kinase Inhibitor II, RepSox, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
• Formule empirique (notation de Hill) : C₁₇H₁₃N₅
• Numéro CAS: 446859-33-2
• Poids moléculaire : 287.32
• Numéro MDL: MFCD09037561
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥99% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Température de stockage: −70°C
• Chaîne SMILES: [nH]1ncc(c1c4nc(ccc4)C)c2nc3c(nccc3)cc2
• InChI: 1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
• Clé InChI: LBPKYPYHDKKRFS-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC₅₀ = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC₅₀ >16 µM).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
ALK5

Reversible: yes

Target IC₅₀: 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Forme physique

A 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.

Autres remarques

Ichida, J. K., et al. 2009. Cell Stem Cell5, 491.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - (refers to pure substance)
• Point d'éclair (°C): 87 °C - (refers to pure substance)