5.05026

DNQX Disodium Salt

• Synonyme(s) : DNQX Disodium Salt, AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX
• Formule empirique (notation de Hill) : C₈H₂N₄Na₂O₆
• Numéro CAS: 2379-57-9
• Poids moléculaire : 296.10
• Numéro MDL: MFCD00069257
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: dark brown
• Solubilité: H₂O: 100 mM
• Température de stockage: 2-8°C
• Chaîne SMILES: [N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1[N+](=O)[O-])=O)=O
• InChI: 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• Clé InChI: RWVIMCIPOAXUDG-UHFFFAOYSA-N

Description

Description générale

A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC₅₀ = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.

Actions biochimiques/physiologiques

Primary Target
AMPA

Secondary Target
GluK2

Target IC₅₀: 0.19 to 1.66 uM

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable