C239

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

• Synonyme(s) : 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
• Formule empirique (notation de Hill): C₉H₂N₄Na₂O₄ · xH₂O
• Numéro CAS: 115066-14-3
• Poids moléculaire : 276.12 (anhydrous basis)
• Numéro MDL: MFCD09953908
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277972
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: CNQX disodium salt hydrate, ≥98% (HPLC), solid
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light
• Couleur: orange to red
• Solubilité: H₂O: >2 mg/mL (warmed)
• Chaîne SMILES: O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
• InChI: 1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
• Clé InChI: LCDWHGXMFAZHEO-UHFFFAOYSA-L
• Informations sur le gène: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Description

Application

CNQX disodium salt hydrate has been used as:

• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Actions biochimiques/physiologiques

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist.[1] It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs).[2] It displays micromolar affinity towards AMPA/kainate receptor.[3]

Potent, competitive AMPA/kainate receptor antagonist.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)