235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

• Synonyme(s) : Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
• Formule empirique (notation de Hill): C₂₁H₃₀O₄
• Numéro CAS: 50-22-6
• Poids moléculaire : 346.46
• Numéro MDL: MFCD00037715
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Corticosterone, Corticosteroid hormone synthesized in response to stress.
• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: crystalline powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white; white to tan
• Solubilité: ethanol: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• Chaîne SMILES: O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clé InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

Description générale

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3