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220551

Sigma-Aldrich

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Synonyme(s) :

Chloramphenicol

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About This Item

Formule empirique (notation de Hill):
C11H12Cl2N2O5
Numéro CAS:
56-75-7
Poids moléculaire :
323.13
Numéro MDL:
MFCD00078159
Code UNSPSC :
12352200

Niveau de qualité

100

Pureté

≥97% (by Assay)

Forme

crystalline powder

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Couleur

gray to off-white

Solubilité

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

Conditions d'expédition

ambient

Température de stockage

10-30°C

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)

Clé InChI

WIIZWVCIJKGZOK-UHFFFAOYSA-N

Catégories apparentées

Description générale

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.
Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Actions biochimiques/physiologiques

Potency: ≥970 µg/mg
Primary Target
trasnslation of RNA

Autres remarques

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Health hazardCorrosion
GHS08,GHS05

Mention d'avertissement

Danger

Mentions de danger

H318,H351,H361fd

Classification des risques

Carc. 2 - Eye Dam. 1 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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