730998

tBuBrettPhos

97%

• Synonyme(s) : t-Bu Brett Phos, t-BuBrett-Phos, tertButylBrettPhos, 2-(Di-tert-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl, t-BuBrett Phos, t-BuBrettPhos, [3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl) [1,1′-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine, tert-ButylBrettPhos
• Formule empirique (notation de Hill): C₃₁H₄₉O₂P
• Numéro CAS: 1160861-53-9
• Poids moléculaire : 484.69
• Numéro MDL: MFCD13181930
• Code UNSPSC : 12352112
• ID de substance PubChem : 329764610
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 300
• Pureté: 97%
• Forme: solid
• Capacité de réaction: reaction type: Cross Couplings
• Pertinence de la réaction: reagent type: ligand; reaction type: Arylations; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: C-X Bond Formation; reagent type: ligand; reaction type: Fluorinations
• Pf: 166-170 °C
• Groupe fonctionnel: phosphine
• Chaîne SMILES: COc1ccc(OC)c(c1P(C(C)(C)C)C(C)(C)C)-c2c(cc(cc2C(C)C)C(C)C)C(C)C
• InChI: 1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3
• Clé InChI: REWLCYPYZCHYSS-UHFFFAOYSA-N

Description

Description générale

tBuBrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.

tBuBrettPhos is a phosphine ligand widely used in palladium-catalyzed cross-coupling reactions.

Application

Buchwald Phosphine Ligands for chemical Synthesis

Common applications

• Buchwald-Hartwig amination and C-O coupling
• Suzuki, Negishi, Stille, Hiyama, Sonogashira cross-couplings
• α-Arylation reaction

New Applications:

• Conversion of aryl and vinyl triflates to bromides and chlorides
• Conversion of aryl triflates to aryl fluorides
• O-Arylation of ethyl acetohydroximate
• Conversion of aryl chlorides and sulfonates to nitroaromatics

Caractéristiques et avantages

• White crystalline solid
• Air- and moisture-stable
• Thermally stable
• Highly efficient
• Wide functional group tolerance
• Excellent selectivity and conversion

Informations légales

Usage subject to US Patent 7,858,784

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable