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Merck

TRPV1

transient receptor potential cation channel, subfamily V, member 1

Synonymes:
VR1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(7442) Summary: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(193034) transient receptor potential cation channel, subfamily V, member 1
  • Rat(83810) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(101093406) transient receptor potential cation channel, subfamily V, member 1
  • chicken(395259) transient receptor potential cation channel, subfamily V, member 1
  • naked mole-rat(101720480) transient receptor potential cation channel, subfamily V, member 1
  • Domestic Rabbit(100008926) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(100303454) transient receptor potential cation channel, subfamily V, member 1
  • Zebrafish(561195) transient receptor potential cation channel, subfamily V, member 1
  • cow(539074) transient receptor potential cation channel, subfamily V, member 1
  • domestic guinea pig(100135466) transient receptor potential cation channel, subfamily V, member 1
  • Horse(100034158) transient receptor potential cation channel, subfamily V, member 1
  • sheep(101110158) transient receptor potential cation channel, subfamily V, member 1
  • dog(445457) transient receptor potential cation channel, subfamily V, member 1

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Espèce(s)
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Espèce(s)
rat
N-Oleoylethanolamine, ~98% (TLC),
Espèce(s)
human, mouse, rat

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
SB-366791, ≥98% (HPLC), powder,
Espèce(s)
human
6-Iodonordihydrocapsaicin, ≥98% (HPLC), solid,
Espèce(s)
human
Capsazepine, ≥98% (HPLC), solid,
Espèce(s)
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Espèce(s)
rat, human
Capsaicin, natural,
Espèce(s)
rat, human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-TRPV1 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
western blot
Anti-Capsaicin Receptor Antibody, CT, serum, Chemicon®,
Espèces réactives
rat
Application
immunohistochemistry
Anti-Capsaicin Receptor Antibody, NT, serum, Chemicon®,
Espèces réactives
mouse, primate, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-TRPV1 antibody produced in mouse, clone 1F5, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
Anti-TRPV1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
Olvanil, powder,
Espèce(s)
human
Acétaminophène, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Capsaicin, ≥95%, from Capsicum sp.,
Espèce(s)
rat, human
Acétaminophène, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Acétaminophène, BioXtra, ≥99.0%,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Numéro du produit
Description
Espèce(s)
N-Vanillylnonanamide, ≥97%, powder,
Espèce(s)
rat
Capsazepine, ≥98% (HPLC), solid,
Espèce(s)
human, rat

Small Molecule - Opener

Numéro du produit
Description
Espèce(s)
Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Capsaicin, analytical standard,
Espèce(s)
human
Capsaicin, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Capsaicin, phyproof® Reference Substance,
Espèce(s)
human
Capsaicin, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human TRPV1,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Trpv1,
Espèce(s)
mouse